Study Suggests New Treatment for Hidradenitis Suppurativa
March 19, 2017 (San Diego, California) — Six weeks of
compassionate treatment with intravenous (IV) ertapenem resulted in a dramatic
improvement in patients with severe Hidradenitis Suppurativa (HS). The treatment "is hardly seen in the literature
for this disease," reported Aude Nassif, MD, here at the American Academy
of Dermatology 70th Annual Meeting.
"It is the first time an antibiotic with no recognized
anti-inflammatory activity has shown a real efficiency in HS, which raises the
question of an infectious participation," said Dr. Nassif, who is from the
Institute Pasteur in Paris, France.
Despite the response, this therapy must still be considered
an induction Hidradenitis Suppurativa Treatment. "It needs complementary treatment with oral
antibiotics and surgery. It can't prevent this, but it will help to reduce the
number and size of excisions," she said.
The study follows one recently published by her group
(Dermatology. 2011; 222:49-58), which assessed the efficacy of triple therapy
(oral rifampin, moxifloxacin, and metronidazole) in HS patients; "however,
results for stage 3 patients were unsatisfactory," she explained.
With triple therapy, "we kept seeing lapses in stage 3
patient’s right when they stopped metronidazole. This suggested that a more
prolonged antianaerobic treatment could be necessary to treat these patients.
But you can't prolong metronidazole beyond 6 weeks without serious risk of
neuropathy. It is not recommended."
The approach with ertapenem was chosen because "it is
easy to use (a once-a-day IV injection, which allows home treatment), it has a
good tolerance profile," and it covers a wide spectrum of bacteria that
are found in the superinfection of HS lesions.
"Unlike what is commonly thought, microbiological
culture reveals a rich anaerobic bacteria flora in stage 2 and 3 HS
lesions," she said.
Resource link: http://www.medscape.com/viewarticle/760502
Hidradenitis suppurativa, painful, pea-sized lumps. Information about hidradenitis suppurativais include Hidradenitis Suppurativa Natural Treatment, symptoms and causes making diagnosis relatively easy.
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